In our days, shortages in vitamins D3 and K2 have evolved into an epidemic. There are very serious health problems that can be associated with the long-term shortage of vitamins D and K. More specifically, the lack of these vitamins is able to affect the development and stability of the immune system. Serious effects of this deficiency can occur in: Immune system, Musculoskeletal system, Nervous system, Endocrine system. The synergistic effect of D3 & K2 vitamins are critical for healthy calcium metabolism because they play the most essential role in depositing calcium in skeletal tissue.